NBG Journal Club

Discussion Topic: A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies Article Link: https://doi.org/10.1038/s41593-021-00913-6 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Prognostic value of polygenic risk scores for adults with psychosis Article Link: https://www.nature.com/articles/s41591-021-01475-7 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Spatially mapped single-cell chromatin accessibility Article Link: https://www.nature.com/articles/s41467-021-21515-7.pdf Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines Article Link: https://www.sciencedirect.com/science/article/pii/S089662732100427X?via%3Dihub Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Polygenic risk for depression, anxiety and neuroticism are associated with the severity and rate of change in depressive symptoms across adolescence Article Link: https://acamh.onlinelibrary.wiley.com/doi/epdf/10.1111/jcpp.13422 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Coding of social novelty in the hippocampal CA2 region and its disruption and rescue in a 22q11.2 microdeletion mouse model Article Link: https://www.nature.com/articles/s41593-020-00720-5 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Demographic history mediates the effect of stratification on polygenic scores Article Link: https://elifesciences.org/articles/61548 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy Article Link: https://www.pnas.org/content/119/6/e2118688119 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Make war not love: The neural substrate underlying a state-dependent switch in female social behavior Article Link: https://www.sciencedirect.com/science/article/pii/S0896627321009958 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Modeling assortative mating and genetic similarities between partners, siblings, and in-laws Article Link: https://www.nature.com/articles/s41467-022-28774-y Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic:Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level Article Link: https://www.nature.com/articles/s41593-021-00999-y Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset Article Link: https://www.nature.com/articles/s41593-022-01033-5 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk Article Link: https://scholar.harvard.edu/files/tge/files/transcriptional_and_imaging-genetic_association_of_cortical_interneurons_brain_function_and_schizophrenia_risk.pdf Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

In lieu of our typical Journal Club meeting, we will have a predoctoral trainee present on the research they have been conducting under the Training Program in Neurobehavioral Genetics. Research Topic: Investigation of mitochondrial dysfunction mechanisms in Rett syndrome neurons Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Causal effects on complex traits are similar across segments of different continental ancestries within admixed individual Article Link: https://doi.org/10.1101/2022.08.16.22278868 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Causal effects on complex traits are similar across segments of different continental ancestries within admixed individual Article Link: https://www.science.org/doi/10.1126/science.abq5011 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Genetic heterogeneity shapes brain connectivity in psychiatry Article Link: https://www.sciencedirect.com/science/article/pii/S0006322322015529 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participants Article Link: https://pubmed.ncbi.nlm.nih.gov/31104335/ Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour. Article Link: https://www.nature.com/articles/s41467-019-09576-1 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Autism genes converge on asynchronous development of shared neuron classes Article Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8852827/ Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic:A biomarker-authenticated model of schizophrenia implicating NPTX2 loss of function Article Link: https://www.science.org/doi/10.1126/sciadv.abf6935 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic:Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour Article Link: https://www.nature.com/articles/s41586-022-05161-7 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors Article Link: https://www.science.org/doi/10.1126/science.adf0435 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic:Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel Article Link: https://jamanetwork.com/journals/jamaneurology/fullarticle/2771828 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Mapping of clonal lineages across developmental stages in human neural differentiation Article Link: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00044-9 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Neural Mechanism of Prosocial Comforting Behavior Article Link: N/A Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders Article Link: https://www.nature.com/articles/s41380-022-01854-7.pdf Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Assembloid CRISPR screens reveal impact of disease genes in human neurodevelopment Article Link: https://www.nature.com/articles/s41586-023-06564-w Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: BrainGENIE: The Brain Gene Expression and Network Imputation Engine Article Link: https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2811397 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Shared Genetic Risk in the Association of Screen Time With Psychiatric Problems in Children Article Link: https://jamanetwork.com/journals/jamanetworkopen/article-abstract/2811397 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu

Discussion Topic: Genetic correlates of social stratification in Great Britain Article Link: https://www.nature.com/articles/s41562-019-0757-5 Zoom URL: Provided upon request from CNGT32@mednet.ucla.edu